80
million people living with glaucoma worldwide
111.8
million estimated number of glaucoma patients by 2040
2.4
million people diagnosed with glaucoma each year (est.)
11
million people estimated to be bilaterally blind due to glaucoma in 2020
12%
of all new cases of legal blindness each year caused by glaucoma
FILLING
AN
UNMET
NEED
The consortium’s primary aim is to advance scientific knowledge in the field of glaucoma, with an emphasis on highly myopic eyes with and without glaucoma and non-highly myopic eyes with early glaucoma. “We believe the Consortium will fill the unmet need to structurally phenotype glaucoma and myopia, separately and as comorbidities using OCT,” explained Dr. Claude F. Burgoyne, Principal Investigator for the GMOPC and Senior Scientist and Van Buskirk Chair for Ophthalmic Research Director, Optic Nerve Head Research Laboratory at Devers Eye Institute in Portland, Oregon. “We see this as an opportunity to foster collaboration among leading researchers, develop and share rich data sets for use in deep learning and standardize the structural definitions for glaucoma.”
THE GMOPC MEMBERS
Executive Committee
Ophthalmologist and Glaucoma Specialist
Legacy Good Samaritan Hospital & Medical Center
Claude Burgoyne
GMOPC Principal
Investigator
Professor & Research Director of Ophthalmology and Visual Sciences
Nova Scotia Health, Dalhousie University
Balwantray Chauhan
Clinical Review
Co-Principal Investigator
Professor of Ophthalmology
University of California, San Diego
Linda Zangwill
Reading Center
Co-Principal Investigator
Scientific Director
Heidelberg Engineering GmbH
Charles Reisman
Executive Director
GMOPC Participating
Clinical Sites
Hong Kong University
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MD
Christopher Leung is Head and Professor in the Department of Ophthalmology at the University of Hong Kong, where he also serves as the Director of Glaucoma and Optic Nerve Research Center. He read a MSc in Molecular Medicine at Imperial College London and completed a clinical and research fellowship at the Hamilton Glaucoma Center, UCSD.
His research focuses on glaucoma diagnostics, optical coherence tomography, and neuroprotection. The research and service awards he received include the ARVO Clinician-Scientist Research Award (2010), World Glaucoma Association Science Award (2009 and 2011), APAO Nakajima Award (2010), AAO Achievement Award (2015) and Secretariat Award (2012), and WITSA Global Information and Communications Excellence Award (2019), among others.
Beijing Tongren Hospital
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Yaxing Wang
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MD
Christopher Leung is Head and Professor in the Department of Ophthalmology at the University of Hong Kong, where he also serves as the Director of Glaucoma and Optic Nerve Research Center. He read a MSc in Molecular Medicine at Imperial College London and completed a clinical and research fellowship at the Hamilton Glaucoma Center, UCSD.
His research focuses on glaucoma diagnostics, optical coherence tomography, and neuroprotection. The research and service awards he received include the ARVO Clinician-Scientist Research Award (2010), World Glaucoma Association Science Award (2009 and 2011), APAO Nakajima Award (2010), AAO Achievement Award (2015) and Secretariat Award (2012), and WITSA Global Information and Communications Excellence Award (2019), among others.
Columbia University
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Don Hood
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Emmanouil (Manos) Tsamis
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MD
Christopher Leung is Head and Professor in the Department of Ophthalmology at the University of Hong Kong, where he also serves as the Director of Glaucoma and Optic Nerve Research Center. He read a MSc in Molecular Medicine at Imperial College London and completed a clinical and research fellowship at the Hamilton Glaucoma Center, UCSD.
His research focuses on glaucoma diagnostics, optical coherence tomography, and neuroprotection. The research and service awards he received include the ARVO Clinician-Scientist Research Award (2010), World Glaucoma Association Science Award (2009 and 2011), APAO Nakajima Award (2010), AAO Achievement Award (2015) and Secretariat Award (2012), and WITSA Global Information and Communications Excellence Award (2019), among others.
Devers Eye Institute
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Stuart Gardiner
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Claude Burgoyne
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Brad Fortune
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Steven L. Mansberger
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Hongli Yang
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Christopher Leung is Head and Professor in the Department of Ophthalmology at the University of Hong Kong, where he also serves as the Director of Glaucoma and Optic Nerve Research Center. He read a MSc in Molecular Medicine at Imperial College London and completed a clinical and research fellowship at the Hamilton Glaucoma Center, UCSD.
His research focuses on glaucoma diagnostics, optical coherence tomography, and neuroprotection. The research and service awards he received include the ARVO Clinician-Scientist Research Award (2010), World Glaucoma Association Science Award (2009 and 2011), APAO Nakajima Award (2010), AAO Achievement Award (2015) and Secretariat Award (2012), and WITSA Global Information and Communications Excellence Award (2019), among others.
Friedrich Alexander University
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Bettina Hohberger
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Christian Mardin
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MD
Christopher Leung is Head and Professor in the Department of Ophthalmology at the University of Hong Kong, where he also serves as the Director of Glaucoma and Optic Nerve Research Center. He read a MSc in Molecular Medicine at Imperial College London and completed a clinical and research fellowship at the Hamilton Glaucoma Center, UCSD.
His research focuses on glaucoma diagnostics, optical coherence tomography, and neuroprotection. The research and service awards he received include the ARVO Clinician-Scientist Research Award (2010), World Glaucoma Association Science Award (2009 and 2011), APAO Nakajima Award (2010), AAO Achievement Award (2015) and Secretariat Award (2012), and WITSA Global Information and Communications Excellence Award (2019), among others.
Inje University Heaundae Paik Hospital
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Min Hee Suh
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MD
Christopher Leung is Head and Professor in the Department of Ophthalmology at the University of Hong Kong, where he also serves as the Director of Glaucoma and Optic Nerve Research Center. He read a MSc in Molecular Medicine at Imperial College London and completed a clinical and research fellowship at the Hamilton Glaucoma Center, UCSD.
His research focuses on glaucoma diagnostics, optical coherence tomography, and neuroprotection. The research and service awards he received include the ARVO Clinician-Scientist Research Award (2010), World Glaucoma Association Science Award (2009 and 2011), APAO Nakajima Award (2010), AAO Achievement Award (2015) and Secretariat Award (2012), and WITSA Global Information and Communications Excellence Award (2019), among others.
Kanazawa University
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Tomomi Higashide
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Kazuhisa Sugiyama
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Christopher Leung is Head and Professor in the Department of Ophthalmology at the University of Hong Kong, where he also serves as the Director of Glaucoma and Optic Nerve Research Center. He read a MSc in Molecular Medicine at Imperial College London and completed a clinical and research fellowship at the Hamilton Glaucoma Center, UCSD.
His research focuses on glaucoma diagnostics, optical coherence tomography, and neuroprotection. The research and service awards he received include the ARVO Clinician-Scientist Research Award (2010), World Glaucoma Association Science Award (2009 and 2011), APAO Nakajima Award (2010), AAO Achievement Award (2015) and Secretariat Award (2012), and WITSA Global Information and Communications Excellence Award (2019), among others.
Nova Scotia Health - Dalhousie University
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Marcelo Nicolela
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Balwantray Chauhan
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Christopher Leung is Head and Professor in the Department of Ophthalmology at the University of Hong Kong, where he also serves as the Director of Glaucoma and Optic Nerve Research Center. He read a MSc in Molecular Medicine at Imperial College London and completed a clinical and research fellowship at the Hamilton Glaucoma Center, UCSD.
His research focuses on glaucoma diagnostics, optical coherence tomography, and neuroprotection. The research and service awards he received include the ARVO Clinician-Scientist Research Award (2010), World Glaucoma Association Science Award (2009 and 2011), APAO Nakajima Award (2010), AAO Achievement Award (2015) and Secretariat Award (2012), and WITSA Global Information and Communications Excellence Award (2019), among others.
Seoul National University Hospital
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Jin Wook Jeoung
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MD
Christopher Leung is Head and Professor in the Department of Ophthalmology at the University of Hong Kong, where he also serves as the Director of Glaucoma and Optic Nerve Research Center. He read a MSc in Molecular Medicine at Imperial College London and completed a clinical and research fellowship at the Hamilton Glaucoma Center, UCSD.
His research focuses on glaucoma diagnostics, optical coherence tomography, and neuroprotection. The research and service awards he received include the ARVO Clinician-Scientist Research Award (2010), World Glaucoma Association Science Award (2009 and 2011), APAO Nakajima Award (2010), AAO Achievement Award (2015) and Secretariat Award (2012), and WITSA Global Information and Communications Excellence Award (2019), among others.
Tajimi Iwase Eye Clinic
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Aiko Iwase
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Christopher Leung is Head and Professor in the Department of Ophthalmology at the University of Hong Kong, where he also serves as the Director of Glaucoma and Optic Nerve Research Center. He read a MSc in Molecular Medicine at Imperial College London and completed a clinical and research fellowship at the Hamilton Glaucoma Center, UCSD.
His research focuses on glaucoma diagnostics, optical coherence tomography, and neuroprotection. The research and service awards he received include the ARVO Clinician-Scientist Research Award (2010), World Glaucoma Association Science Award (2009 and 2011), APAO Nakajima Award (2010), AAO Achievement Award (2015) and Secretariat Award (2012), and WITSA Global Information and Communications Excellence Award (2019), among others.
University of California, Los Angeles (UCLA)
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Kouros Nouri-Mahdavi
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Joseph Caprioli
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Christopher Leung is Head and Professor in the Department of Ophthalmology at the University of Hong Kong, where he also serves as the Director of Glaucoma and Optic Nerve Research Center. He read a MSc in Molecular Medicine at Imperial College London and completed a clinical and research fellowship at the Hamilton Glaucoma Center, UCSD.
His research focuses on glaucoma diagnostics, optical coherence tomography, and neuroprotection. The research and service awards he received include the ARVO Clinician-Scientist Research Award (2010), World Glaucoma Association Science Award (2009 and 2011), APAO Nakajima Award (2010), AAO Achievement Award (2015) and Secretariat Award (2012), and WITSA Global Information and Communications Excellence Award (2019), among others.
University of California, San Diego (UCSD)
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Linda Zangwill
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Robert N. Weinreb
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Andrew Camp
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Christopher Leung is Head and Professor in the Department of Ophthalmology at the University of Hong Kong, where he also serves as the Director of Glaucoma and Optic Nerve Research Center. He read a MSc in Molecular Medicine at Imperial College London and completed a clinical and research fellowship at the Hamilton Glaucoma Center, UCSD.
His research focuses on glaucoma diagnostics, optical coherence tomography, and neuroprotection. The research and service awards he received include the ARVO Clinician-Scientist Research Award (2010), World Glaucoma Association Science Award (2009 and 2011), APAO Nakajima Award (2010), AAO Achievement Award (2015) and Secretariat Award (2012), and WITSA Global Information and Communications Excellence Award (2019), among others.
University of Campinas
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Vital Costa
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Christopher Leung is Head and Professor in the Department of Ophthalmology at the University of Hong Kong, where he also serves as the Director of Glaucoma and Optic Nerve Research Center. He read a MSc in Molecular Medicine at Imperial College London and completed a clinical and research fellowship at the Hamilton Glaucoma Center, UCSD.
His research focuses on glaucoma diagnostics, optical coherence tomography, and neuroprotection. The research and service awards he received include the ARVO Clinician-Scientist Research Award (2010), World Glaucoma Association Science Award (2009 and 2011), APAO Nakajima Award (2010), AAO Achievement Award (2015) and Secretariat Award (2012), and WITSA Global Information and Communications Excellence Award (2019), among others.
THE GMOPC
Vision
The Glaucoma / Myopia OCT Phenotyping Consortium (GMOPC) was established in February 2020 at an inaugural meeting in Los Angeles, California, as an investigator-initiated clinical research study, inspired by the collaborative spirit of Principle Investigator, Claude Burgoyne, and the Heidelberg Engineering co-founder, the late Dr. Gerhard Zinser. The consortium comprises 13 clinical centers in seven countries, and provides a new research platform for acquiring OCT images, data storage and retrieval for efficient review, quality control, and secure access.
Governed by a Charter Agreement entered into on October 18, 2021, GMOPC Members will facilitate the collection and sharing of data and diagnostic images to foster scientific exchange and advancements in the field of glaucoma, with an emphasis on highly myopic eyes with and without glaucoma and non-highly myopic eyes with early glaucoma. This project, initiated by Dr. Claude Burgoyne, is the first of this magnitude in which a team of researchers collaborates in hopes of improving OCT detection of non-highly myopic early structural glaucoma and better understanding myopic structural abnormality and myopic structural glaucoma.
The GMOPC is an international, coordinated, and collaborative approach to support
research into the early detection of glaucoma, the world’s leading cause of irreversible vision loss. Looking beyond established risk factors for glaucoma such as age, family history and intraocular pressure, GMOPC investigators have established five goals to gain scientific insights intended to ultimately help clinicians detect glaucoma earlier and improve patient care:
THE GMOPC
Mission
To characterize OCT structural normality in healthy eyes
To improve the OCT detection of non-highly myopic early structural glaucoma
To better understand myopic structural abnormality and myopic structural glaucoma
To lay the foundations for secure data sharing to support Machine Learning on an international scale
To establish a powerful platform for further international research initiatives.
LEVERAGING
TEchnology
The consortium’s primary objective is the advancement of scientific knowledge. In pursuit of this objective, the scientific focus revolves around the development of a scalable imaging and data management solution to foster scientific exchange. The consortium’s efforts will also help improve the performance of the SPECTRALIS® imaging platform in highly myopic patients. Heidelberg Engineering (HE) is supporting the mission of the GMOPC investigators with HEYEX SHARE*, a comprehensive suite of hardware and software: ANTERION® for capturing anterior chamber and biometry data, a next generation SPECTRALIS for posterior segment imaging, HEYEX EMR with new functionality configured specifically for clinical trials, and HEYEX PACS, a powerful platform for image management and third-party device integration, to facilitate secure data sharing within the global research community.
As a member and industry partner of the consortium, HE is loaning to each of the other members diagnostic devices free of charge to facilitate the collection of data and establish a data-sharing platform for compilation and sharing of collected data and further the Research Plan of the consortium.
HEYEX SHARE* is an integrated platform comprising Electronic Data Capture, Image
Management, and the technology needed to drive study workflow and secure data transfer.
*Special Heidelberg Advanced Research Environment
In accordance with the GMOPC mission, clinical investigators will collate three powerful new data sets: one consisting of highly myopic patients without glaucoma, the second of highly myopic patients with glaucoma, and a third of non-highly myopic patients with early glaucoma. The protocols have been painstakingly designed to address a series of unanswered questions in the detection of glaucoma and myopic structural abnormality.
“A further goal is to visually integrate ONH, pp RNFL, and macula OCT imaging data within clinically intuitive dashboards. This multimodal approach will help enable better patient outcomes,” said Dr. Burgoyne.
AN ITERATIVE PROCESS TOWARD BETTER PATIENT OUTCOMES
Further Reading
© 2022 GMOPC